Some examples include equipment, which you can equip to creature cards to give them new abilities or make them more powerful
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If they never see any new cards, and dont have any answers to your threats on the board, you can effectively stop them from playing the game
March of the Machine has introduced a staggering number of two-card death combos
For example, Blades of Velis Vel and Volatile Claws may look roughly equal to each other in a vacuum, but Blades having changeling means it costs 1 less thanks to The Ur-Dragon, can be tutored up with Sliver Overlord, and can be cast from the graveyard with Haakon, Stromgald Scourge, making it far superior
In short, the adapted controls and smaller scale wont get in your way of winning thats all on your skill...and cards