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There are, what, 3 versions of Vraska that create "You lose the game" effects

While this one does present the risk of languishing in your hand for some time, you still get three modes that can get you out of trouble, because countering instants will often mean protecting a key creature on your side of the board from a removal spell

Crunching numbers is their specialty

Commanders : Lead with Magus Lucea Kane , a powerful commander who amplifies your X-spells and accelerates your Tyranid swarm

III Return target Assassin creature card from your graveyard to the battlefield with an additional +1/+1 counter on it

That's a pretty big deal, and it's remained a pretty big deal for over a decade now