DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg SHP099 is a highly potent

SHP099 is a highly potent (IC50 = 0

Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C44H69N7O17 Molecular Weight 968

92 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)NCC#C)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)N(CCCS([O-])(=O)=O)C2=CC=C(C=C12)S(O)(=O)=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

10-tetraazacyclododecane-1

43 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCCCN=[N]#N)C1=CC=C(O)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg SHP099 is a highly potentSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further