Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg Product Name tert-butyl 2-[4-(piperazin-1-yl)piperidin-1-yl]acetate Synonyms

Product Name tert-butyl 2-[4-(piperazin-1-yl)piperidin-1-yl]acetate Synonyms 1-Piperidineacetic acid

Product Name NRX-1933 Synonyms CAS Number 2763260-30-4 Related CAS Molecular Formula C14H9F3N6O2 Molecular Weight 350

821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NCCCCCNS(=O)(=O)C1=CC=C(C(=C1)S([O-])(=O)=O)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C83H136N12O23 Molecular Weight 1670

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg Product Name tert-butyl 2-[4-(piperazin-1-yl)piperidin-1-yl]acetate SynonymsSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan,