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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Trametinib (GSK1120212
Product Name DOTA-tris(t-Bu)ester-C3-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C31H59N5O8 Molecular Weight 629
5-TAMRA has also achieved prominence as a dye for oligonucleotide labeling and automated DNA sequencing applications
Product Name CA-SS-BODIPY Synonyms BODIPY Halotag Ligand Cleavable CAS Number N/A Related CAS N/A Molecular Formula C29H43BClF2N3O4S2 Molecular Weight 646
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE peg4 DCAF1-based PROTACs with activity againstSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to
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