DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:25mg 587 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCN2C(=O)C=CC2=O)=[N+](C)C)=C1 Purity (HPLC):

587 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCN2C(=O)C=CC2=O)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

715 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-CO-C3-Br Synonyms Pomalidomide-4'-CO-C3-Br CAS Number 2227423-26-7 Related CAS Molecular Formula C17H16BrN3O5 Molecular Weight 422

Cancers 2021

with a Kd value of 69 nM towards DCAF1 measured by fluorescence polarization

DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:25mg 587 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCN2C(=O)C=CC2=O)=[N+](C)C)=C1 Purity (HPLC):SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further