Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE deuterium-labeled-amine Fitzgibbons

Fitzgibbons

originally isolated from Rhodococcus rhodochrous

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate CAS Number 159857-81-5 Related CAS Molecular Formula C35H43N7O11 Molecular Weight 737

Product Name 6-FAM C2 maleimide Synonyms CAS Number N/A Related CAS Molecular Formula C27H18N2O8 Molecular Weight 498

64 SMILES Cl

Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE deuterium-labeled-amine FitzgibbonsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate