2'-O-4'-C-Locked-A(Bz) phosphoramidite 2'-O-MOE Phosphoramidites and Donald H

and Donald H

" Kidney International 61

It contains a bicyclic ribose in which a methylene bridge connects the 2’-oxygen (O) and 4’-carbon (C)

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2'-O-4'-C-Locked-A(Bz) phosphoramidite 2'-O-MOE Phosphoramidites and Donald H2 O 4 C Locked A(Bz) phosphoramidite is a locked nucleic acid (LNA) phosphoramidite monomer for solid phase oligonucleotide synthesis. It contains a bicyclic ribose in which a methylene bridge connects the 2 oxygen (O) and 4 carbon (C), locking the sugar in a C3 endo conformation. It also contains an adenine (A) with benzoyl (Bz) base protection, a 5 dimethoxytrityl (DMT) group for 5 hydroxyl protection, and a cyanoethyl (CE) protecting group on