DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB nitrogen 1038/s41586-020-2760-4

1038/s41586-020-2760-4

009 Purity (HPLC) >= 95% Solubility DMSO

054 SMILES [2H]C([2H])([2H])OC1=CC=CC=C1Br Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

specifically in the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction

DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB nitrogen 1038/s41586-020-2760-4SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing