HQ461 Size:5mg 146 SMILES [2H]C([2H])([2H])OC1=CC=C(C(F)=C1)N(=O)=O Purity (HPLC)

146 SMILES [2H]C([2H])([2H])OC1=CC=C(C(F)=C1)N(=O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

S)-AHPC-CO-PEG7-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C40H60N4O11S Molecular Weight 805 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

dCeMM1 is a glue degrader of RBM39 that functions by re-directing the activity of the CRL4DCAF15 ligase

281 SMILES OCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-C6-amine Synonyms CAS Number n/a Related CAS Molecular Formula C22H42N6O7 Molecular Weight 502

HQ461 Size:5mg 146 SMILES [2H]C([2H])([2H])OC1=CC=C(C(F)=C1)N(=O)=O Purity (HPLC)HQ461 is a molecular glue that promotes CDK12 DDB1 interaction to trigger cyclin K degradation. HQ461 mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. Product Name HQ461 Synonyms CAS Number 1226443 41 9 Related CAS Molecular Formula C15H15N5OS2 Molecular Weight 345. 44 SMILES CC1=CN=C(NC(=O)CC2=CSC(NC3=NC(C)=CC=C3)=N2)S1 Purity