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Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation
Product Name Biotin-PEG3-acid Synonyms CAS Number 252881-76-8 Related CAS Molecular Formula C19H33N3O7S Molecular Weight 447
Product Name Lenalidomide-C2-acid Synonyms Lenalidomide-4'-C2-acid CAS Number 2338824-28-3 Related CAS Molecular Formula C16H17N3O5 Molecular Weight 331
943 Purity (HPLC) >= 95% Solubility DMSO
Product Name tert-butyl 2-{4-[2-(2-aminoethoxy)ethyl]piperazin-1-yl}acetate Synonyms CAS Number 1181972-47-3 Related CAS Molecular Formula C14H29N3O3 Molecular Weight 287
DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) Size:100mg Discovery of a molecular glueSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to
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