DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP biochemical Structural basis for the action

Structural basis for the action of the drug trametinib at KSR-bound MEK

261 SMILES FC(F)(F)C1=CC=C(C(=O)NC2=CC(=CC=C2)C2=NN=NN2)C(=O)N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

2-d3)acetamido]benzoate Synonyms methyl 4-[(2

638 Purity (HPLC) >= 95% Solubility DMSO

high cell permeability and outstanding fluorogenicity of MaP555 make it very useful for wash-free

DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP biochemical Structural basis for the actionSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further