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The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides
789 Purity (HPLC) >= 95% Solubility DMSO
599 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(OCCOCCOCCOCCOCCOCCOCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C60H90N8O25 Molecular Weight 1323
Product Name Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C42H66N6O16 Molecular Weight 911
Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-MMAE mal-acetyl-dap-m-PEG4 The propargyl functional group isSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
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