Propargy-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Size:25mg 8 SMILES ClCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

8 SMILES ClCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

making it ideal for aqueous-based applications without requiring organic solvents

The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG4 moiety to enhance aqueous solubility

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

Chloroquinaxoline sulfonamide (CQS) promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase for degadation

Propargy-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Size:25mg 8 SMILES ClCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing