Yes, you can put lessons in your main deck
GAME CHANGERS Game Changers are cards that can dramatically warp Commander games, allowing players to run away with resources, shift games in ways that many players dislike, block people from play, efficiently search for their strongest cards, or have commanders that tend to take away from more casual games
If youre sure it cant be removed, this is excellent
Fortisphere is good for early draw and can be left for later to give Bodygaurd just when you need it
If you're counting on Winged Sliver or Muscle Sliver or any other boost to carry you through combat, then a removal spell on the key ability can destroy your entire team, and even with Hibernation Sliver available such a blow is often crippling
A lot of voices in the community have already complained about some of the design choices in Magic, like how a lot of the lore is lost in the sheer abundance thats thrown at you in a short visit to a new plane