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For instance, in an Archimandrite deck you could gain a bunch of life in your upkeep and first main phase to add a big +X/+0 buff to your commander, then use Alteration to turn it into Giggling Skitterspike

10 Cut In Red mana is usually tied with black mana for the best removal in any expansion set, including cards like Cut In

Stacking these up could be interesting, and it's not a must stop kind of effect that your opponents absolutely must get in the way of

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How Does Emrakul Work

Other effects that interact with putting counters on it will interact with this effect accordingly