Im specifically talking about Giver of Runes, Esper Sentinel, and Grand Abolisher for the early game and Burning-Rune Demon and Razaketh, the Foulblooded for later
Whether it's destroying something your opponent controls or helping you fix your lands, there are all sorts of powerful effects that Panharmonicon lets you double up on
As far as asymmetrical hatebears go, this is one of the strongest in the Commander format
Tameshi provides an added incentive for playing bounce spells as she allows you to draw a card once per turn as long as something is bounced
"Unfair" decks tend to contain the potential for serious abuse with narrow, powerful cards that can do ridiculous things when the plan comes together
On top of that, its a 7/7 flier that deals at least 5 damage to players trying to kill it