In the mid and late game you'll probably have the mana to use it and still do something else on your turn
So all you have to do with Karumonix is build a fairly straightforward Phyrexian Rat deck, find a few ways to get them to slip through some combat damage, and start watching those poison counters tick up
Dredgers Insight This sort of 2-mana self-mill cantrip isnt particularly uncommon in green, but Dredger's Insight is interesting largely because its an enchantment
My second point is a comment based on the feedback I have seen from people watching me stream this deck
In my analysis of Eldrazi Displacer, I mentioned an easy combo would be the Displacer + Brood Monitor + Zulaport Cutthroat
Up the Beanstalk isnt really a problem right now, but if Standard slows down after the next ban announcement, Dark Confidant could be the card that lets a bunch of smaller mana value decks tick