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Probably all the others combined, in fact

Enigma Thief Interacting with all opponents at once is the name of the game in Commander

(Each in the mana costs of permanents you control counts toward your devotion to blue.) Creature - Wizard Merfolk Draw (CTRL to add secondary) Enchantment Merseine Enchant creature This Aura enters with three net counters on it

Honorable Mentions Legendary Creatures Rubinia Soulsinger seems to be so Commander-friendly that it was even reprinted in Commander 2013

The issue is that it's random, and we already have cards like Wildest Dreams, Long Rest, and Harness Infinity in the format, none of which see meaningful play

Your most comprehensive form of instant speed protection is Teferi's Protection which not only keeps your board safe, but also stops most forms of interaction with you until your next turn