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and MIA PaCa-2 cells
and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8
inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cells
BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays
Almorexant HCl is an orally active
Dabrafenib (GSK2118436) Pore and MIA PaCa-2 cellsDabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0. 7 nM in cell free assays, with 7 and 9 fold less potency against B Raf(wt) and c Raf, respectively.
